mglur1 antagonist cpccoet Search Results


hydroxyiminocyclopropan  (Tocris)
94
Tocris hydroxyiminocyclopropan
Hydroxyiminocyclopropan, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mglur1+antagonist+cpccoet/CPCCOEt/pm19094988-108-36-47
Average 94 stars, based on 1 article reviews
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mglur1 antagonist cpccoet  (Tocris)
93
Tocris mglur1 antagonist cpccoet
Figure 6. Reduced membrane depolarization and <t>mGluR1</t> activation in STIM1 KO PNs. A, Line plot of the mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on 75 mM KCl stimulation (STIM1WT, 84 PNs, 8 mice; STIM1PKO, 44 PNs, 5 mice). B, Representative images of changes in GCaMP6f fluorescence from PN soma at indicated time points fol- lowing KCl stimulation. Red arrowheads indicate PN soma. Scale bars, 20mm. C-E, Bar graphs with peak DF/F (STIM1WT, 12.41 6 0.57; STIM1PKO, 7.086 0.40; p = 4.10 1012), area under the curve (STIM1WT, 360.21 6 27.82; STIM1PKO, 273.59 6 31.92, p = 0.04338), and rate of calcium entry DF/Sec (STIM1WT, 2.546 0.27; STIM1PKO, 0.566 0.04, p = 2.11 1010) quantified from A, respectively. Each bar is compared with control shown in blue. *p , 0.05; **p , 0.0001; two-tailed Student’s t test. Line plots of GCaMP6f fluorescence responses (DF/F) in PN soma of (F) control (30 PNs, 4 mice) and (G) STIM1PKO (55 PNs, 4 mice) on addition of the mGluR1 agonist, 200 mM DHPG. H, Snapshots of GCaMP6f responses from PN soma at indicated time points on DHPG stimulation. Red arrowheads indicate the PN soma. Scale bars, 20mm. I, Mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on DHPG stimulation in slices incubated with 200 mM CPCCOEt, an mGluR1 antagonist (STIM1WT, 39 PNs, 4 mice; STIM1PKO, 43 PNs, 4 mice).
Mglur1 Antagonist Cpccoet, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mglur1+antagonist+cpccoet/CPCCOEt/10__1523_slash_jneurosci__2401___20__2021-110-1-4
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selective mglur1 antagonist cpccoet  (Federation of European Neuroscience Societies)
90
Federation of European Neuroscience Societies selective mglur1 antagonist cpccoet
Figure 6. Reduced membrane depolarization and <t>mGluR1</t> activation in STIM1 KO PNs. A, Line plot of the mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on 75 mM KCl stimulation (STIM1WT, 84 PNs, 8 mice; STIM1PKO, 44 PNs, 5 mice). B, Representative images of changes in GCaMP6f fluorescence from PN soma at indicated time points fol- lowing KCl stimulation. Red arrowheads indicate PN soma. Scale bars, 20mm. C-E, Bar graphs with peak DF/F (STIM1WT, 12.41 6 0.57; STIM1PKO, 7.086 0.40; p = 4.10 1012), area under the curve (STIM1WT, 360.21 6 27.82; STIM1PKO, 273.59 6 31.92, p = 0.04338), and rate of calcium entry DF/Sec (STIM1WT, 2.546 0.27; STIM1PKO, 0.566 0.04, p = 2.11 1010) quantified from A, respectively. Each bar is compared with control shown in blue. *p , 0.05; **p , 0.0001; two-tailed Student’s t test. Line plots of GCaMP6f fluorescence responses (DF/F) in PN soma of (F) control (30 PNs, 4 mice) and (G) STIM1PKO (55 PNs, 4 mice) on addition of the mGluR1 agonist, 200 mM DHPG. H, Snapshots of GCaMP6f responses from PN soma at indicated time points on DHPG stimulation. Red arrowheads indicate the PN soma. Scale bars, 20mm. I, Mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on DHPG stimulation in slices incubated with 200 mM CPCCOEt, an mGluR1 antagonist (STIM1WT, 39 PNs, 4 mice; STIM1PKO, 43 PNs, 4 mice).
Selective Mglur1 Antagonist Cpccoet, supplied by Federation of European Neuroscience Societies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mglur1+antagonist+cpccoet/mglur+antagonists/pm11168529-148-27-8
Average 90 stars, based on 1 article reviews
selective mglur1 antagonist cpccoet - by Bioz Stars, 2026-09
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Image Search Results


Figure 6. Reduced membrane depolarization and mGluR1 activation in STIM1 KO PNs. A, Line plot of the mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on 75 mM KCl stimulation (STIM1WT, 84 PNs, 8 mice; STIM1PKO, 44 PNs, 5 mice). B, Representative images of changes in GCaMP6f fluorescence from PN soma at indicated time points fol- lowing KCl stimulation. Red arrowheads indicate PN soma. Scale bars, 20mm. C-E, Bar graphs with peak DF/F (STIM1WT, 12.41 6 0.57; STIM1PKO, 7.086 0.40; p = 4.10 1012), area under the curve (STIM1WT, 360.21 6 27.82; STIM1PKO, 273.59 6 31.92, p = 0.04338), and rate of calcium entry DF/Sec (STIM1WT, 2.546 0.27; STIM1PKO, 0.566 0.04, p = 2.11 1010) quantified from A, respectively. Each bar is compared with control shown in blue. *p , 0.05; **p , 0.0001; two-tailed Student’s t test. Line plots of GCaMP6f fluorescence responses (DF/F) in PN soma of (F) control (30 PNs, 4 mice) and (G) STIM1PKO (55 PNs, 4 mice) on addition of the mGluR1 agonist, 200 mM DHPG. H, Snapshots of GCaMP6f responses from PN soma at indicated time points on DHPG stimulation. Red arrowheads indicate the PN soma. Scale bars, 20mm. I, Mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on DHPG stimulation in slices incubated with 200 mM CPCCOEt, an mGluR1 antagonist (STIM1WT, 39 PNs, 4 mice; STIM1PKO, 43 PNs, 4 mice).

Journal: The Journal of Neuroscience

Article Title: Purkinje Neurons with Loss of STIM1 Exhibit Age-Dependent Changes in Gene Expression and Synaptic Components

doi: 10.1523/jneurosci.2401-20.2021

Figure Lengend Snippet: Figure 6. Reduced membrane depolarization and mGluR1 activation in STIM1 KO PNs. A, Line plot of the mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on 75 mM KCl stimulation (STIM1WT, 84 PNs, 8 mice; STIM1PKO, 44 PNs, 5 mice). B, Representative images of changes in GCaMP6f fluorescence from PN soma at indicated time points fol- lowing KCl stimulation. Red arrowheads indicate PN soma. Scale bars, 20mm. C-E, Bar graphs with peak DF/F (STIM1WT, 12.41 6 0.57; STIM1PKO, 7.086 0.40; p = 4.10 1012), area under the curve (STIM1WT, 360.21 6 27.82; STIM1PKO, 273.59 6 31.92, p = 0.04338), and rate of calcium entry DF/Sec (STIM1WT, 2.546 0.27; STIM1PKO, 0.566 0.04, p = 2.11 1010) quantified from A, respectively. Each bar is compared with control shown in blue. *p , 0.05; **p , 0.0001; two-tailed Student’s t test. Line plots of GCaMP6f fluorescence responses (DF/F) in PN soma of (F) control (30 PNs, 4 mice) and (G) STIM1PKO (55 PNs, 4 mice) on addition of the mGluR1 agonist, 200 mM DHPG. H, Snapshots of GCaMP6f responses from PN soma at indicated time points on DHPG stimulation. Red arrowheads indicate the PN soma. Scale bars, 20mm. I, Mean traces (6SEM) of normalized GCaMP6f fluorescence responses (DF/F) in PN soma on DHPG stimulation in slices incubated with 200 mM CPCCOEt, an mGluR1 antagonist (STIM1WT, 39 PNs, 4 mice; STIM1PKO, 43 PNs, 4 mice).

Article Snippet: An mGluR1 antagonist CPCCOEt (Tocris Bioscience, catalog #1028) of 200 mM was applied to test for the specificity of mGluR1 activation (Hartmann et al., 2008).

Techniques: Membrane, Activation Assay, Fluorescence, Control, Two Tailed Test, Incubation

Figure 13. Schematic representation of age-dependent STIM1 functions in cerebellar PNs. The ER-Ca21 sensor STIM1 lies at the heart of intracellular Ca21 signaling in PNs. Loss of STIM1 attenuates Ca21 entry and affects refilling of ER stores, which suppresses mGluR1-stimulated Ca21 signals and PN excitability. Over time, these changes affect gene expression and optimal synaptic connectivity of cerebellar PNs. Phrases in blue represent changes in STIM1PKO PNs that occur over 17 weeks. Phrases in red represent longer-term changes observed at 1 year. The schematic encapsulates novel findings from this work and from previous studies (Hartmann et al., 2014; Ryu et al., 2017). Model created using Biorender (www.BioRender.com).

Journal: The Journal of Neuroscience

Article Title: Purkinje Neurons with Loss of STIM1 Exhibit Age-Dependent Changes in Gene Expression and Synaptic Components

doi: 10.1523/jneurosci.2401-20.2021

Figure Lengend Snippet: Figure 13. Schematic representation of age-dependent STIM1 functions in cerebellar PNs. The ER-Ca21 sensor STIM1 lies at the heart of intracellular Ca21 signaling in PNs. Loss of STIM1 attenuates Ca21 entry and affects refilling of ER stores, which suppresses mGluR1-stimulated Ca21 signals and PN excitability. Over time, these changes affect gene expression and optimal synaptic connectivity of cerebellar PNs. Phrases in blue represent changes in STIM1PKO PNs that occur over 17 weeks. Phrases in red represent longer-term changes observed at 1 year. The schematic encapsulates novel findings from this work and from previous studies (Hartmann et al., 2014; Ryu et al., 2017). Model created using Biorender (www.BioRender.com).

Article Snippet: An mGluR1 antagonist CPCCOEt (Tocris Bioscience, catalog #1028) of 200 mM was applied to test for the specificity of mGluR1 activation (Hartmann et al., 2008).

Techniques: Gene Expression